host cell response – Communicable Diseases Research

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

Article

Published on 2022-11-052022-11-15
Journal: Scientific Reports
[Category] SARS, 신약개발, 치료제,

SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

Article

Published on 2022-10-012022-11-16
Journal: Nature
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells

Research Article

Published on 2022-02-022022-10-30
Journal: Life Science Alliance
[Category] COVID-19, COVID19(2023년), MERS, SARS,

Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection

비교 전 사체 분석은 SARS-CoV-2 감염의 주요 후성 유전 적 표적을 나타냅니다

Article

Published on 2021-05-242022-09-10
Journal: NPJ Systems Biology and Applications
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome coronavirus 2 analysis Analysis analyzed Candidates caused cell line cell lines change Comparative coronavirus COVID-19 current described effort EP300 Epigenetic Factor feasible gene co-expression network host cell host cell response Infection involved MERS MERS-CoV molecular mechanism molecular mechanisms MOV10 outbreak pathway pathway enrichment Protein Regulation Regulatory networks RELA Research respiratory respiratory syndrome coronavirus 2 reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Systems analysis target therapeutic options therapeutic potential transcription factors Transcriptional changes Transcriptome transcriptomes treat TRIM25 Viral viral infection
[DOI] 10.1038/s41540-021-00181-x PMC 바로가기 [Article Type] Article

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

인간 호흡기 상피에서 SARS-CoV-2 및 SARS-CoV에 대한 서로 다른 온도 의존성 바이러스-숙주 역학

Research Article

Published on 2021-03-292022-08-13
Journal: PLoS Biology
[Category] Biochemistry, COVID-19, SARS,

[키워드] acute respiratory syndrome coronavirus Affect both virus both viruses Cell culture characteristic clinical feature coronavirus coronavirus 2 CoV infection epithelial epithelial cell exhibit Host host cell host cell response host innate immune response dynamics human respiratory epithelium human-to-human transmission dynamics infected individuals Infection influence innate immune response interferon investigated Lower respiratory tract performed Phylogenetic relationship primary human airway primary human airway epithelial cell culture model pro-inflammatory response pro-inflammatory responses public health replicated Replication replication efficiency replication kinetics respiratory respiratory viruses SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread temperature temperature-dependent interferon These data time-resolved transcriptome analysis Transcriptome transcriptome analysis transmission efficiencies type I type III interferon upper respiratory epithelium upper respiratory tract Viral viral replication viral replication kinetics virus–host dynamics virus–host interaction dynamics viruses
[DOI] 10.1371/journal.pbio.3001158 PMC 바로가기 [Article Type] Research Article

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Pharmacology

Published on 2020-11-092022-10-31
Journal: Frontiers in Pharmacology
[Category] COVID-19,

[키워드] activate acute respiratory syndrome adaptive Anti-viral Antiviral Antiviral compound antiviral drug approach approach approaches approved drug benefit cause chaperone clinical development clinical trials coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patients CoVs Drug repurposing drugs Endoplasmic reticulum ER membranes ER stress expected facilitate Health host cell host cell response host protein identify in vitro Infection infections interact Interaction interfere Intervention Ligand mechanism Medicine membrane-bound modulation occur pathway patients potential mechanism Prevent professional protective immune response Proteins provide receptor reduce regulate Repurposed drugs repurposing SARS-CoV-2 SARS-CoV-2 protein sigma-1 receptor Stress targeting the disease therapeutic therapy treat unique upstream viral replication
[DOI] 10.3389/fphar.2020.582310 PMC 바로가기 [Article Type] Pharmacology

The viral protein fragment theory of COVID-19 pathogenesis

코로나19 발병기전의 바이러스 단백질 단편 이론

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses
[Category] SARS, 치료법,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus addition affected affecting amplification can not cardiovascular disease Cell Cell signaling Complication components conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients develop elicited event events explained fatal COVID-19 fusion host cell host cell response host cells Human Hypothesis include infected individual infected individuals infected with SARS-CoV-2 infecting inhibit Interaction observation occur pandemic Patient Release Replication respiratory respiratory virus resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling single-stranded RNA virus Spike protein surface protein surface proteins target host cell the SARS-CoV-2 the spike protein Therapeutics thought to define treat Vascular Viral viral capsid Viral protein viral replication virus viruses while
[DOI] 10.1016/j.mehy.2020.110267 PMC 바로가기 [Article Type] Article

A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

Article

Published on 2020-08-242022-10-31
Journal: Cells
[Category] COVID-19, MERS,

[키워드] alternative splicing analysis antigen processing antigen-presentation BAL Calu3 Cell cell line cellular CMV Concentration contributing to Cytokines determinant dose elements enzyme ERAP2 ERAP2/Iso3 expressing expression flu healthy subject HIV-1 host cell response Human immune response in vitro Infectious disease influenza infection interferon-stimulated genes isoforms LPS MDM MHC class I microbial infections modulation MOI mRNA mRNA expression New pathogen pathogenicity Pathogens PBMC PBMCs peptide Protein protein expression Result role SARS-CoV-2 SARS-CoV-2 antigen stimulated target to define translated variant viruses
[DOI] 10.3390/cells9091951 PMC 바로가기 [Article Type] Article

Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon Resolution

Genome Replication and Regulation of Viral Gene Expression

Published on 2019-06-262022-10-30
Journal: Journal of Virology
[Category] Coronavirus, MERS,

[키워드] Analysis avian coronavirus Cell cellular changes in chick coding region Comparative complex conserved Coronaviruses data set Differential gene expression differentially expressed downstream Efficiency expand facilitated form Frame Gene Expression gene network generate Genome genomic RNA High-resolution host cell response host genes IBV IBV infection Improved include indicated Infection Infectious Bronchitis Virus isolates kidney Like Molecular biology mRNA transcript nucleocapsid occur ORF ORF4b pathogen pathogenic positive-sense quantification Replication Resolution ribosome profiling RNA genome RNA virus RNAseq Sequencing sgmRNA sgmRNA transcripts sgmRNAs Single nucleotide polymorphism single-stranded Spread strain Strains subgenomic mRNA Transcription translation translational Triplet upregulation Vaccination strategy vaccine candidate Variation viral RNA synthesis virus virus infection
[DOI] 10.1128/JVI.00714-19 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다

Research Article

Published on 2016-07-222022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence
[DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article